The Seven Hills Depot began operation in the late 1950s and was owned by Messers, Willmott and Holman. This was sold in the 1960s to C.H. Webb Brothers who also operated Granville Coaches. In 1974, C.H. Webb Brothers purchased Blacktown Bus Company and merged this with the Seven Hills operations to form Seven Hills Bus Co.

This consisted of 18 buses operating from the Seven Hills Depot. In 1980, the company was sold to the nearby Toongabbie Bus Service, which was owned by the Delfs Family. This service became part of Westbus in the mid 1980s.

Hillsbus Seven Hills is now a member of ComfortDelGro Cabcharge and still operates from the original depot today. The depot is situated near Seven Hills Railway Station, has a staff of approximately 52 and a fleet of 34 vehicles.